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Dosage/Direction for Use. nexium 40 mg Adult Initially 4-80 mg daily. glimepiride 3 mg Maintenance: 4-8 mg daily, may increase dose to 16 mg daily if necessary Childn Initially 0 8-1 1 mg/kg Maintenance: 2-4 mg daily, may increase dose to 8 mg daily if necessary Adjuvant therapy in Addison's disease 4-8 mg daily, may increase to 16 mg in stressful situations